Studies and Articles

Articles

 

Cannabinoid drug interactions

CBD Drug Interactions: Taking CBD with Prescription Drugs

Cannabis and Arthritis

Cannabis Could Be Reversing Damage to Arthritic Joints

Cannabis and weight loss

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users

Cannabis and cancer

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Medical Marijuana Can Kill Viability In Melanoma Cancer Cells

IS CANNABIS A VIABLE TREATMENT FOR MELANOMA?

When it comes to cancer treatment, the plant may have an amazing impact when used in concert with traditional therapies. Combining CBD and THC with conventional treatments may be the best synergy for cancer sufferers.

Man With “Terminal” Lung Cancer Cures Himself With Cannabis Oil

RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

Oncologists and Cannabis

Medical Oncologists’ Beliefs, Practices, and Knowledge Regarding Marijuana Used Therapeutically: A Nationally Representative Survey Study

Cannabis and Chemotherapy

Study: CBD From Marijuana Plus Chemotherapy Tripled Cancer Survival Rates In Mice

Marijuana Is a Wonder Drug When It Comes to the Horrors of Chemo

Hemp vs. Cannabis

What’s the difference between marijuana CBD and hemp CBD?

The Benefits of THCA

https://www.crescolabs.com/cannabinoids/thca/

What Is THCA & What Are the Benefits of This Cannabinoid?

Cannabis and Acne

Cannabidiol as a Treatment for Acne?

The Importance of Terpenes

TERPENES: SMELL THE MYSTERY: Terpenes are compounds that give cannabis its unique smell and make each strain unique. Terpenes have important therapeutic effects, as well.

Cannabis and Parkinson’s Disease

The endocannabinoid system and digestive imbalance play major roles in Parkinson's disease. Research on CBD, THC, and THCV has demonstrated that cannabis medicine may help to manage PD symptoms.

Cannabis and Memory/Dementia/Alzheimers Disease

Daily Dose Of Cannabis May Protect And Heal The Brain From Effects Of Aging

Medical marijuana is safe and effective for elderly people with MS, sleep problems, and Parkinson's, study finds

Cannabis, Anandamide and the Endocannabinoid System

What Is the Endocannabinoid System and What Is Its Role?

Anandamide — The Body’s Own Antidepressant And How To Boost It Naturally

https://www.kalapa-clinic.com/en/what-is-anandamide/

CBD Dosing

CBD Oil Dosage: General Tips to Assess How Much CBD to Take

Cannabis and Pets

Researchers Aim to Determine the Efficacy and Safety of Cannabis in Dogs

The Science Behind Giving CBD & Cannabis to Cats and Dogs

Still wondering if CBD oil lives up to the hype, or if you’ll go to jail for recommending it? New research from Cornell backs the claims, and the federal government seems to be loosening the noose on veterinary recommendations.

Full Extract Cannabis Oil

Strain Review: Understanding the Power of Full Extract Cannabis Oil: The potent extract (also known as FECO, Rick Simpson Oil, or “RSO”) is the most potent medicine available.

Cannabis and Opioids

https://www.miamiherald.com/news/nation-world/national/article133816674.html

Cannabis and Diverticulitis

https://thefreshtoast.com/cannabis/the-role-cannabis-plays-in-treating-diverticulitis/


Scientific Research (courtesy Dr. Junella Chin)


Addiction
    •    Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
    •    Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
    •    Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
    •    Cannabis as a substitute for alcohol and other drugs
    •    Interactions between delta9-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys
    •    Involvement of the endocannabinoid system in drug addiction
    •    Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

Alzheimer's/Dementia
  
    •    Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease
    •    Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
    •    Cannabinoids for the treatment of dementia
    •    Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
  
    •   Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
    •    Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
    •    Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer’s disease
    •    Synthetic cannabinoids in dementia with agitation: case studies and literature review
    •    The influence of cannabinoids on generic traits of neurodegeneration
  
Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's)
    •    Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid
    •    Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials
    •    Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival

Antibacterial
    •    Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
    •    Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
    •    Antimicrobial Activity of Cannabis sativa L.
    •    Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
    •    Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
    •    In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains
    •    Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses

Antioxidant
    •    Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
    •    Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
    •    Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
    •    Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
    •    Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
    •    Neuroprotective antioxidants from marijuana
    •    Oxyradical Stress, Endocannabinoids, and Atherosclerosis
    •    Prospects for cannabinoid therapies in basal ganglia disorders
    •    Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death

Antiprion
    •    Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity

Anxiety
    •    Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
    •    Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
    •    Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
    •    Cannabinoid-related agents in the treatment of anxiety disorders- current knowledge and future perspectives
    •    Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
    •    Effects of Cannabidiol (CBD) on Regional Cerebral Blood
    •    Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
    •    Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
    •    Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice

Appetite
    •    Endocannabinoids, feeding and suckling – from our perspective
    •    Endogenous cannabinoid system as a modulator of food intake
    •    Hypothalamic POMC neurons promote cannabinoid-induced feeding
    •    The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Arthritis
    •    Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
    •    Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
    •    Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes
    •    Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis

Asthma
    •    Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma

Attention Deficit Hyperactivity Disorder (ADHD)
    •    Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
    •    Cannabis improves symptoms of ADHD
    •    Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder
    •    Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)
    •    Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition

Autism
    •    Alterations in the endocannabinoid system in the rat valproic acid model of autism
    •    Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
    •    Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders
    •    Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
    •    Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
    •    Endocannabinoid System as Novel Therapeutic Target for Autism Treatment
    •    Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression
    •    Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
    •    Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child
    •    Uncoupling of the endocannabinoid signaling complex in a mouse model of fragile X syndrome
    •    Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

Autoimmune
    •    Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
    •    Cannabinoids as novel anti-inflammatory drugs
    •    Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Batten Disease
    •    Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
    •    Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
    •    Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
    •    Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
    •    Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins
    •    siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycineinduced cell migration

Breast Cancer
    •    Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
    •    Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
    •    Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
    •    Cannabinoids: A new hope for breast cancer therapy
    •    Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
    •    Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
    •    Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.
    •    Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
    •    Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
    •    The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

Cancer
    •    A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
    •    A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    •    Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
    •    Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
    •    Anticancer mechanisms of cannabinoids
    •    Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells
    •    Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    •    Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    •    Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
    •    Antitumorigenic Effects of Cannabinoids beyond Apoptosis
    •    Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
    •    Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
    •    Cannabidiol as potential anticancer drug
    •    Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
    •    Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus Infected Endothelium
    •    Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
    •    Cannabinoid-associated cell death mechanisms in tumor models (Review)
    •    Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
    •    Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
    •    Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies
    •    Cannabinoid Receptor-Mediated Apoptosis Induced by R()-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
    •    Cannabinoid receptors as novel targets for the treatment of melanoma
    •    Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
    •    Cannabinoids and Cancer
    •    Cannabinoids and cancer: pros and cons of an antitumour strategy
    •    Cannabinoids and ceramide: Two lipids acting hand-by-hand
    •    Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
    •    Cannabinoids as therapeutic agents in cancer: current status and future implications
    •    Cannabinoids, Endocannabinoids and Cancer
    •    Cannabinoids for Cancer Treatment: Progress and Promise
    •    Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    •    Cannabinoids: potential antitumoral agents
    •    Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
    •    Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
    •    Cannabis and Cannabinoids (PDQ®) - National Cancer Institute
    •    Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
    •    Cannabis in Cancer Care
    •    CBD inhibits angiogenesis by multiple mechanisms
    •    Ceramide: a new second messenger of cannabinoid action
    •    Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
    •    COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
    •    Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    •    Differential role of cannabinoids in the pathogenesis of skin cancer
    •    Endocannabinoids and Cancer
    •    Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
    •    Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review)
    •    Endocannabinoids as Guardians of Metastasis
    •    Endocannabinoids in endocrine and related tumours
    •    Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
    •    Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
    •    Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
    •    Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
    •    Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
    •    High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    •    Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
    •    In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
    •    Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism
    •    Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
    •    Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    •    Inhibition of tumor angiogenesis by cannabinoids
    •    Integrating cannabis into clinical cancer care
    •    Involvement of PPARc in the antitumoral action of cannabinoids on hepatocellular carcinoma
    •    Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
    •    Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
    •    Medical marijuana for cancer
    •    Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
    •    Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
    •    Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
    •    Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2
    •    Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines
    •    Proapoptotic effect of endocannabinoids in prostate cancer cells
    •    Receptor-dependent and receptor-independent endocannabinoid signaling: A therapeutic target for regulation of cancer growth
    •    Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
    •    Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
    •    Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    •    The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
    •    The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    •    The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
    •    The endocannabinoid system and cancer: therapeutic implication
    •    The endocannabinoid system in cancer- Potential therapeutic target?
    •    The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    •    The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas
    •    The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma
    •    The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
    •    The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    •    The use of cannabinoids as anticancer agents
    •    Towards the use of cannabinoids as antitumour agents
    •    United States patent application publication for phytocannabinoids in the treatment of cancer

Cannabidiol (CBD)
    •    5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
    •    Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
    •    An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse
    •    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    •    Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
    •    Cannabidiol in Humans—The Quest for Therapeutic Targets
    •    Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
    •    Cannabidiol: Promise and Pitfalls
    •    Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
    •    Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

CBDV
    •    Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
    •    Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

Cardiovascular
    •    Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
    •    Blood pressure regulation by endocannabinoids and their receptors
    •    Cannabinoids in experimental stroke: a systematic review and meta-analysis
    •    Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
    •    Is the cardiovascular system a therapeutic target for cannabidiol?
    •    Oxyradical Stress, Endocannabinoids, and Atherosclerosis
    •    Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
    •    STUDIES INVESTIGATING THE MECHANISMS OF THE CARDIOPROTECTIVE EFFECTS OF CANNABIDIOL
    •    Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

CB1 Receptor
    •    Allosteric Modulation of the Cannabinoid CB1 Receptor
    •    Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
    •    Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
    •    Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
    •    Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
    •    Enhanced acetylcholine release in the hippocampus of cannabinoid
    •    Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
    •    Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
    •    Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
    •    Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

CB2 Receptor
    •    Activation of cannabinoid receptor type II by AM1241 protects adipose-derived mesenchymal stem cells from oxidative damage
    •    Cannabinoid Type 2 Receptors Mediate a Cell Type Specific Plasticity in the Hippocampus
    •    CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
    •    Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
    •    Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    •    Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
    •    The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    •    Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Cellular Function
    •    Anti-inflammatory Potential of CB1-mediated CAMP Elevation in Mast Cells
    •    Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
    •    Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
    •    Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Cerebral Palsy
    •    Survey Results of Pain Treatments in Adults with Cerebral Palsy

Cognition
    •    Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
    •    Effects of cannabis on cognitive function in patients with multiple sclerosis
    •    Keep off the grass Cannabis? Cognition and addiction
    •    Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition

Colon Cancer
    •    Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
    •    Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
    •    Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
    •    Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
    •    Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent
    •    Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
    •    Possible endocannabinoid control of colorectal cancer growth
    •    The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
    •    The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
    •    The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Crohn's Disease
    •    Cannabis Alleviates Symptoms Of Crohn’s Disease
    •    Cannabis Finds Its Way into Treatment of Crohn’s Disease
    •    Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study
    •    Treatment of Crohn’s Disease with Cannabis: An Observational Study

D9-Tetrahydrocannabinol (THC)
    •    A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    •    A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
•    Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
    •    Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
    •    Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
    •    BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
    •    Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
    •    Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
    •    Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
    •    Consumption and Quantitation of D9-Tetrahydrocannabinol in Commercially Available Hemp Seed Oil Products
    •    D9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    •    D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
    •    Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
    •    Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
    •    Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
    •    Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
    •    Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
    •    Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
    •    Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses
    •    Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
    •    Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
    •    Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
    •    Preliminary, open-­label, pilot study of add-­on oral Δ9-­tetrahydrocannabinol in chronic post-­traumatic stress disorder
    •    Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
    •    The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
    •    The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
    •    The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
    •    Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

D9-Tetrahydrocannabinolic acid (THCA)
    •    Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of D9-Tetrahydrocannabinolic Acid A.pdf

Depression
    •    Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
    •    Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
    •    Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Diabetes
    •    Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
    •    Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
    •    Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells
    •    Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    •    Novel Study Reports Marijuana Users Have Better Blood Sugar Control
    •    Presence of functional cannabinoid receptors in human endocrine pancreas
    •    The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
    •    The endocannabinoid system in obesity and type 2 diabetes
    •    The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium Dependent Mechanisms

Drug Interactions
    •    A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers
    •    Cannabis and its effect on anesthesia

Edema
    •    Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

Emesis
    •    Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
    •    Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
    •    Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
    •    Regulation of nausea and vomiting by cannabinoids
    •    The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus
    •    The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

Endocannabinoid System (ECS)
    •    Abnormalities in neuroendocrine stress response in psychosis- the role of endocannabinoids
    •    Agonistic Properties of Cannabidiol at 5-HT1a Receptors
    •    Anandamide and 2-arachidonoylglycerol- pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids
    •    Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
    •    Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus: Site and Mechanism of Action
    •    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    •    Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors
    •    Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
    •    Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    •    Cannabinoid pharmacology: the first 66 years
    •    Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
    •    Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
    •    Cannabis and endocannabinoid modulators: Therapeutic promises and challenges
    •    Cannabis, a complex plant: different compounds and different effects on individuals
    •    Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
    •    Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
    •    Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
    •    Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
    •    Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
    •    Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
    •    Endocannabinoid CB1 receptor-mediated rises in Ca2+ and depolarization-induced suppression of inhibition
    •    Endocannabinoid signalling and the deteriorating brain
    •    Endocannabinoid Signaling Regulates Sleep Stability
    •    Endocannabinoids and energy homeostasis: An update
    •    Endocannabinoid System in First Trimester Placenta- Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
    •    Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol
    •    Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
    •    Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
    •    Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
    •    Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
    •    Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
    •    Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
    •    Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
    •    Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system
    •    Modulating the endocannabinoid system in human health and disease: successes and failures
    •    Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity
    •    Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol
    •    Recent advances in cannabinoid receptor agonists and antagonists
    •    Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
    •    Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
    •    Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities
    •    The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
    •    The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
    •    The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease
    •    The endocannabinoid system and migraine
    •    The Endocannabinoid System as an Emerging Target of Pharmacotherapy
    •    The Endocannabinoid System, Cannabinoids, and Pain
    •    The endocannabinoid system drives neural progenitor proliferation
    •    The endocannabinoid system in normal and pathological brain ageing
    •    The endogenous cannabinoid system and its role in nociceptive behavior
    •    The orphan receptor GPR55 is a novel cannabinoid receptor
    •    The therapeutic potential of novel cannabinoid receptorsEndocrine System
    •    Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
    •    Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
    •    Gynecomastia and cannabis smoking A nonassociation among US Army soldiers
    •    Presence of functional cannabinoid receptors in human endocrine pancreas
    •    The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat
    •    The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Epilepsy
    •    Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
    •    Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
    •    Assessment of the role of CB receptors in cannabinoid 1 anticonvulsant effects
    •    Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
    •    Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
    •    Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
    •    Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
    •    Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
    •    Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
    •    Cannabidivarin is anticonvulsant in mouse and rat
    •    Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
    •    Cannabinoids for pediatric epilepsy? Up in smoke or real science?
    •    Cannabinoids in the Treatment of Epilepsy
    •    Cannabis, Cannabinoids and Tinnitus
    •    CANNABIS IN THE MANAGEMENT AND TREATMENT OF SEIZURES AND EPILEPSY: A SCIENTIFIC REVIEW
    •    CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience
    •    Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
    •    Epidiolex (Cannabidiol) in Treatment Resistant Epilepsy
    •    Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
    •    Marijuana Use in Epilepsy: The Myth and the Reality
    •    On the application of cannabis in paediatrics and epileptology
    •    Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy
    •    Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
    •    The case for assessing cannabidiol in epilepsy
    •    The case for medical marijuana in epilepsy
    •    The current status of artisanal cannabis for the treatment of epilepsy in the United States
    •    The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
    •    The Pharmacological Basis of Cannabis Therapy for Epilepsy
    •    Understanding Cannabinoids and Epilepsy
    •    Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se

Fibromyalgia
    •    Association of Herbal Cannabis Use With Negative Psychosocial Parameters in Patients With Fibromyalgia
    •    Marijuana Rated Most Effective for Treating Fibromyalgia

Fibrosis
  • Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy
  • Cannabinoids, inflammation, and fibrosis

Gastrointestinal Disease
    •    Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
    •    Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
    •    Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
    •    Cannabinoids and the gastrointestinal tract
    •    Cannabis Alleviates Symptoms Of Crohn’s Disease
    •    Cannabis Finds Its Way into Treatment of Crohn’s Disease
    •    Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study
    •    Cannabis use amongst patients with inflammatory bowel disease
    •    Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
    •    Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
    •    Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
    •    The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
    •    Treatment of Crohn’s Disease with Cannabis: An Observational Study

General
    •    Acute Pulmonary Physiologic Effects of Smoked Marijuana and Oral Δ9-Tetrahydrocannabinol in Healthy Young Men
    •    Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
    •    Cannabinoids in health and disease
    •    Cannabis sativa: The Plant of the Thousand and One Molecules
    •    Chemical constituents of marijuana: The complex mixture of natural cannabinoids
    •    Early phytocannabinoid chemistry to endocannabinoids and beyond
    •    Future of Cannabis and Cannabinoids in Therapeutics
    •    Medical Marijuana: Clearing Away the Smoke
    •    Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    •    Pharmacological actions and therapeutic uses of cannabis and cannabinoids
    •    Phytocannabinoids beyond the Cannabis plant – do they exist?
    •    Plant cannabinoids: a neglected pharmacological treasure trove
    •    Review on clinical studies with cannabis and cannabinoids 2010-2014
    •    Safety and Toxicology of Cannabinoids
    •    Therapeutic aspects of cannabis and cannabinoids
    •    Therapeutic Benefits of Cannabis: A Patient Survey
    •    The Therapeutic Potential of Cannabis and Cannabinoids
    •    Toward Drugs Derived from Cannabis

Glaucoma
    •    Cannabinoids and glaucoma
    •    Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

Glioblastoma
    •    A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    •    Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
    •    Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
    •    Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
    •    Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

Glioma
    •    A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
    •    Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
    •    Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
    •    Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
    •    Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    •    Cannabinoids as potential new therapy for the treatment of gliomas
    •    Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
    •    Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
    •    Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
    •    Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor
    •    Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma
    •    Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
    •    The Combination of Cannabidiol and D9 -Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

HIV
    •    Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

Immune Function
    •    Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
    •    Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
    •    Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
    •    Cannabinoids and the immune system
    •    Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases
    •    Cannabinoids, Immune System and Cytokine Network
    •    CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
    •    D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
    •    Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    •    Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
    •    Immunoactive effects of cannabinoids: considerations for the therapeutic use of cannabinoid receptor agonists and antagonists
    •    Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57BL/6 Mice

Infant Development
    •    Endocannabinoids, feeding and suckling – from our perspective
    •    Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
    •    The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Inflammation
    •    Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
    •    Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
    •    Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
    •    Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
    •    Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
    •    Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
    •    Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
    •    Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
    •    Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
    •    CANNABINOID-BASED DRUGS AS ANTI-INFLAMMATORY THERAPEUTICS
    •    Cannabinoid CB2 receptors in human brain inflammation
    •    Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
    •    Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
    •    Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases
    •    Cannabinoids as novel anti-inflammatory drugs
    •    Cannabinoids in models of chronic inflammatory conditions
    •    Cannabinoids, inflammation, and fibrosis
    •    Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
    •    Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells
    •    Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
    •    Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation
    •    Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
    •    Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
    •    Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
    •    Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
    •    Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
    •    Oxyradical Stress, Endocannabinoids, and Atherosclerosis
    •    Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
    •    Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
    •    Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
    •    Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid
    •    The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
    •    The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
    •    The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines

Ischemia
    •    Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
    •    Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
    •    Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
    •    Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    •    Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
    •    HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
    •    Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
    •    The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
    •    The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
    •    Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
    •    Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
    •    Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Kidney
    •    Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death
    •    Recreational Marijuana Use is Not Associated with Worse Outcomes After Renal Transplantation

Krabbe disease
    •    Cannabinoids as novel anti-inflammatory drugs
    •    Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    •    CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
    •    Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
    •    Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
    •    The endocannabinoid system as a target for the treatment of neurodegenerative disease
    •    The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
    •    Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis

Leukemia
    •    D9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
    •    Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
    •    Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules

Liver
    •    Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
    •    Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
    •    Endocannabinoids in Liver Disease
    •    Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
    •    Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
    •    Protective effect of cannabidiol against cadmium hepatotoxicity in rats
    •    Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Lung Cancer
    •    Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
    •    Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
    •    Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
    •    Cannabinoids for Cancer Treatment: Progress and Promise
    •    COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
    •    Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    •    Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
    •    Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

Lupus
    •    Cannabinoids, inflammation, and fibrosis
    •    Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids
    •    Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
    •    Recent advances in cannabinoid receptor agonists and antagonists
    •    Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

Lyme Disease
    •    Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
    •    Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
    •    Antimicrobial Activity of Cannabis sativa L.
    •    Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
    •    Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
    •    In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains

Memory
    •    Cannabinoid facilitation of fear extinction memory recall in humans
    •    Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
    •    Keep off the grass Cannabis? Cognition and addiction
    •    Non-acute (residual) neurocognitive effects of cannabis Use: A meta-analytic study
    •    On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
    •    The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
    •    Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons

Mental Illness
    •    Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
    •    β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
    •    Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
    •    Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
    •    Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
    •    Cannabidiol as a potential treatment for psychosis
    •    Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
   •    Cannabidiol, neuroprotection and neuropsychiatric disorders
    •    Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
    •    Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
    •    Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
    •    Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
    •    Cannabis as a substitute for alcohol and other drugs
    •    CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
    •    Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice
    •    Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
    •    Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
    •    Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
    •    Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
    •    Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants
    •    Motor effects of delta 9 THC in cerebellar Lurcher mutant mice
    •    Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
    •    Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report - ResearchGate
    •    Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
    •    The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
    •    The Development of Cannabidiol as a Psychiatric Therapeutic: A Review of Its Antipsychotic Efficacy and Possible Underlying Pharmacodynamic Mechanisms
    •    The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
    •    Therapeutical use of the cannabinoids in psychiatry

Migraine
    •    Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
    •    Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
    •    Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
    •    Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been
    •    Effects of anandamide in migraine: data from an animal model
    •    Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine
    •    The endocannabinoid system and migraine

Mitochondria
    •    Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
    •    Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
    •    Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system

MTHFR Gene Mutation
    •    Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
    •    Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells
    •    Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
    •    Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
    •    Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
    •    Protective effect of cannabidiol against cadmium hepatotoxicity in rats
    •    Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats

Multiple Sclerosis
    •    A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
    •    Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
    •    Cannabinoid Modulation of Neuroinflammatory Disorders
    •    Cannabinoids and multiple sclerosis
    •    Cannabinoids control spasticity and tremor in a multiple sclerosis model
    •    Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
    •    Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
    •    Cannabinoids in the management of spasticity associated with multiple sclerosis
    •    Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    •    Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
    •    Effects of cannabis on cognitive function in patients with multiple sclerosis
    •    Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
    •    Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57BL/6 Mice
    •    Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study
    •    Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
    •    Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
    •    Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
    •    Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
    •    THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms
    •    The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
    •    The effect of cannabis on tremor in patients with multiple sclerosis
    •    The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
    •    Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
    •    Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

National Institute on Drug Abuse (NIDA)
    •    NIDA Research on the Therapeutic Benefits of Cannabis and Cannabinoids

Nausea
    •    Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
    •    Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
    •    Cannabinoid Regulation of Acute and Anticipatory Nausea
    •    Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
    •    Regulation of nausea and vomiting by cannabinoids
    •    The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Nervous System
    •    Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
    •    Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review
    •    Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
    •    Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    •    Phytocannabinoids as novel therapeutic agents in CNS disorders
    •    The effect of cannabichromene on adult neural stem-progenitor cells
    •    Therapeutic Potential of Cannabinoids in CNS Disease

Neuro-protective and Neuro-generative
    •    Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures
    •    An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    •    Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    •    Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
    •    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
    •    Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
    •    Cannabidiol, neuroprotection and neuropsychiatric disorders
    •    Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
    •    Cannabinoid CB2 receptor: a new target for controlling neural cell survival
    •    Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
    •    Cannabinoids and Neuroprotection in Basal Ganglia Disorders
    •    Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
    •    Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    •    Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
    •    Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury
    •    CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
    •    CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
    •    Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
    •    Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
    •    Endocannabinoid Signaling In Neurotoxicity And Neuroprotection
    •    Endocannabinoids and traumatic brain injury
    •    Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
    •    Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
    •    Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
    •    Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
    •    Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
    •    Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
    •    Neuroprotective antioxidants from marijuana
    •    Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    •    Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
    •    Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
    •    Prospects for cannabinoid therapies in basal ganglia disorders
    •    Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
    •    The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
    •    The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
    •    The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K Akt mTORC1 BDNF pathway
    •    The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
    •    The endocannabinoid system as a target for the treatment of neurodegenerative disease
    •    The endocannabinoid system in normal and pathological brain ageing
    •    The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects
    •    United States patent on cannabinoids as antioxidants and neuroprotectants

Neuropathy
    •    An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
    •    Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
    •    Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
    •    Cannabinoids for Neuropathic Pain
    •    Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
    •    Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

Non-Hodgkin's Lymphoma
    •    Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation

Nutrition
    •    An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
    •    Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
    •    The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Obesity
    •    An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
    •    Cannabinoid receptor 2 as anti-obesity target: inflammation, fat storage and browning modulation
    •    Pathophysiological role of host microbiota in the development of obesity
    •    The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
    •    The endocannabinoid system in obesity and type 2 diabetes

Obsessive Compulsive Disorder (OCD)
    •    Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
    •    Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying

Optic Function
    •    Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Organ Transplants
    •    Marijuana Use in Potential Liver Transplant Candidates

Pain
    •    Amygdala activity contributes to the dissociative effect of cannabis on pain perception
    •    An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
    •    Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers- an updated review
    •    Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
    •    Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
    •    Cannabinoid–Opioid Interaction in Chronic Pain
    •    Cannabinoid receptors and pain
    •    Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
    •    Cannabinoids for Neuropathic Pain
    •    Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
    •    Cannabinoids in the management of difficult to treat pain
    •    Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
    •    Cannabinoids with children
    •    Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)
    •    Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
    •    Combined treatment with morphine and Δ9-tetrahydrocannibinol (THC) in rhesus monkeys: antinociceptive tolerance and withdrawal
    •    δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats
    •    Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: An fMRI study in mice
    •    Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
    •    Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
    •    Prescribing cannabis for harm reduction
    •    Role of Cannabinoids in Pain Management
    •    Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
    •    Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
    •    Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
    •    Stable dose cannabinoid medicine GW
    •    Survey Results of Pain Treatments in Adults with Cerebral Palsy
    •    Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
    •    Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
    •    The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
    •    The Endocannabinoid System, Cannabinoids, and Pain
    •    The endogenous cannabinoid system and its role in nociceptive behavior
    •    The Pharmacologic and Clinical Effects of Medical Cannabis
    •    Therapeutic Benefits of Cannabis: A Patient Survey
    •    Use of prescription pain medications among medical cannabis patients: comparisons of pain levels, functioning, and patterns of alcohol and other drug use

Pancreatitis
    •    Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
    •    Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis
    •    Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells

Parkinson's
    •    Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
    •    Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
    •    Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms
    •    The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1-2 phosphorylation in 6-OHDA-lesioned rats
    •    The influence of cannabinoids on generic traits of neurodegeneration

Patents
    •    FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
    •    United States patent application publication for phytocannabinoids in the treatment of cancer
    •    United States patent on cannabinoids as antioxidants and neuroprotectants

Pets
    •    Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Pharmacokinetics
    •    Cannabis in the Arm: What Can we Learn from Intravenous Cannabinoid Studies
    •    Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines
    •    FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
    •    Human Cannabinoid Pharmacokinetics
    •    Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol

Post Traumatic Stress Disorder (PTSD)
    •    Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
    •    Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
    •    Changes of endocannabinoid plasma levels following type I trauma: A prospective pilot study
    •    Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder- A Positron Emission Tomography Study
    •    Endocannabinoid concentrations in hair are associated with PTSD symptom severity
    •    On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
    •    Preliminary, open-­label, pilot study of add-­on oral Δ9-­tetrahydrocannabinol in chronic post-­traumatic stress disorder
    •    PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program

Potential of whole plant vs. single compound model
    •    A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
  • An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
    •    Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
    •    Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts
    •    Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
    •    Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Pregnancy
    •    A Longitudinal Study of Prenatal Marijuana Use
    •    Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
    •    Endocannabinoid System in First Trimester Placenta: Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
    •    Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
    •    Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy
    •    Identifying Prenatal Cannabis Exposure and Effects of Concurrent Tobacco Exposure on Neonatal Growth
    •    Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
    •    Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation
    •    Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development
    •    Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Study
    •    The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Prostate Cancer
    •    Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest
    •    Cannabinoid receptor as a novel target for the treatment of prostate cancer
    •    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines
    •    Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R( þ )-Methanandamide and JWH-015: Involvement of CB2
    •    Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
    •    Proapoptotic effect of endocannabinoids in prostate cancer cells
    •    The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications

Psoriasis
    •    Cannabinoids inhibit human keratinocyte proliferation through a non-CB1-CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

Pulmonary Function
    •    Association Between Marijuana Exposure and Pulmonary Function Over 20 Years
    •    BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
    •    Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
    •    Does smoking marijuana increase the risk of chronic obstructive pulmonary disease
    •    Effects of Marijuana Smoking on the Lung
    •    Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
    •    Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
    •    Marijuana and chronic obstructive lung disease: a population-based study
    •    Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
    •    Preclinical Assessment of Novel Therapeutics on the Cough Reflex: Cannabinoid Agonists as Potential Antitussives
    •    The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study

Schizophrenia
    •    A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches
    •    Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    •    Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
    •    Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
    •    Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

Sickle-cell Disease
    •    Cannabis use in sickle cell disease: a questionnaire study
    •    Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Skeletal System
    •    Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
    •    Cannabinoid receptors and the regulation of bone mass
    •    Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
    •    Cannabinoids and the skeleton: From marijuana to reversal of bone loss
    •    Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone
    •    Peripheral cannabinoid receptor, CB2, regulates bone mass
    •    Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
    •    Role of cannabinoids in the regulation of bone remodeling
    •    The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    •    THE ROLE OF TYPE 2 CANNABINOID RECEPTOR IN BONE METABOLISM

Skin
    •    Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
    •    The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

Sleep
    •    A Longitudinal Study of Prenatal Marijuana Use
    •    A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist-Inverse Agonist AM251 on Sleep in Rats
    •    Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
    •    Around‐the‐Clock Oral THC Effects on Sleep in Male Chronic Daily Cannabis Smokers
    •    Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis
    •    D9 THC as an hypnotic
    •    Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
    •    Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
    •    Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana
    •    Endocannabinoid Signaling Regulates Sleep Stability
    •    Functional role for cannabinoids in respiratory stability during sleep
    •    Intrahippocampal administration of anandamide increases REM sleep
    •    Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat
    •    Modulation of Sleep-Wake Cycles in Mice and Rats with Cannabinoids
    •    Potential Effects of Cannabidiol as a Wake-Promoting Agent
    •    Proof of concept trial of dronabinol in obstructive sleep apnea
    •    The effects of cannabinoid administration on sleep: a systematic review of human studies
    •    The Emerging Role of the Endocannabinoid System in the Sleep-Wake Cycle Modulation
    •    The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

Spasticity
    •    A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
    •    Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
    •    Cannabinoids in the management of spasticity associated with multiple sclerosis
    •    Cannabinoids with children
    •    Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
    •    Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
    •    Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
    •    Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
    •    Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
    •    Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

Sports
    •    Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
    •    Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
    •    Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
    •    Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
    •    An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    •    Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury
    •    Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
    •    Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    •    Cannabinoid agonist rescues learning and memory after a traumatic brain injury
    •    Cannabinoid CB2 Receptor Activation Attenuates Motor and Autonomic Function Deficits in a Mouse Model of Spinal Cord Injury
    •    Cannabinoid receptors and the regulation of bone mass
    •    Cannabinoids and the skeleton: From marijuana to reversal of bone loss
    •    Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report
    •    CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
    •    Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
    •    Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
    •    Endocannabinoids and traumatic brain injury
    •    Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
    •    HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
    •    Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
    •    Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
    •    Peripheral cannabinoid receptor, CB2, regulates bone mass
    •    Role of cannabinoids in the regulation of bone remodeling
    •    The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
    •    The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    •    The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
    •    THE ROLE OF TYPE 2 CANNABINOID RECEPTOR IN BONE METABOLISM
    •    Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
    •    Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
    •    Tissue Engineering of Cartilage; Can Cannabinoids Help?
    •    Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Stroke
    •    Cannabinoids in experimental stroke: a systematic review and meta-analysis
    •    Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
    •    Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Thyroid
    •    Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid

Tourette's syndrome
    •    Cannabinoids for Tourette’s Syndrome (Review)
    •    Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome
    •    Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
    •    Treatment of Tourette syndrome with cannabinoids
    •    Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

Traumatic Brain Injury (TBI)
    •    Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
    •    An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    •    Cannabinoid agonist rescues learning and memory after a traumatic brain injury
    •    CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
    •    Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
    •    Effect of Marijuana Use on Outcomes in Traumatic Brain Injury
    •    Endocannabinoids: A Promising Impact for Traumatic Brain Injury
    •    Endocannabinoids and traumatic brain injury
    •    Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
    •    Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
    •    The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines

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